Journal: Frontiers in Immunology
Article Title: Long-term protective potency of AAV vector-based SARS-CoV-2 prophylaxis in mice and non-human primates
doi: 10.3389/fimmu.2026.1829230
Figure Lengend Snippet: Analysis of serum P2C5-Fc concentration, neutralizing activity, and immunogenicity in mice following i.m. administration of rAAV-P2C5-Fc. (A) Study design. (B) Serum levels of the P2C5-Fc antibody following i.m. administration of rAAV-P2C5-Fc at a dose of a 1.0 × 10 13 gc/kg in mice. (C) NAb activity titers against SARS-CoV-2. (D) Antibody titers against AAV-DJ capsid proteins and the expressed P2C5-Fc antibody.
Article Snippet: The rAAV-P2C5-Fc vector construct was produced using a three-plasmid AAV-DJ packaging system (Cell Biolabs, USA) by transient transfection of HEK293 cells (obtained from the cell collection of the N.F.
Techniques: Concentration Assay, Activity Assay, Immunopeptidomics